Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NMT1 | P30419 | 7/20 | 0.73 |
| ▸ | NMT2 | O60551 | 2/20 | 0.73 |
| ▸ | MAPT | P10636 | 8/20 | 0.62 |
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.62 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.55 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.55 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.55 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.55 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.55 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30532969 | 0.91 | NMT1 (0.64) | NMT1NMT2MAPTLMNAALDH1A1 | |
| SCHEMBL620724 | 0.87 | MAPT (0.61) | NMT1NMT2MAPTLMNAALDH1A1 | |
| SCHEMBL619012 | 0.87 | MAPT (0.56) | NMT1NMT2MAPTLMNAALDH1A1 | |
| SCHEMBL7722117 | 0.84 | MEN1 (0.54) | NMT1NMT2MAPTLMNAALDH1A1 | |
| SCHEMBL620513 | 0.84 | MAPT (0.53) | NMT1NMT2MAPTLMNAALDH1A1 | |
| SCHEMBL544894 | 0.84 | MAPT (0.62) | NMT1MAPTLMNAALDH1A1HPGD | |
| SCHEMBL5929866 | 0.82 | PDGFRB (0.53) | NMT1NMT2MAPTLMNAALDH1A1 | |
| SCHEMBL20775584 | 0.82 | PDGFRB (0.53) | NMT1NMT2MAPTLMNAALDH1A1 | |
| SCHEMBL618676 | 0.82 | MAPT (0.53) | NMT1NMT2MAPTLMNAALDH1A1 | |
| SCHEMBL29896388 | 0.82 | MAPT (0.54) | NMT1NMT2MAPTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7977354-B2 | Heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-alzheimer agents | INSA ROUEN (FR) | 2011-07-12 | — | — | US | disclosed |
| US-7977354-B2 | Heterocyclic compounds, their preparation and their use as medicaments, in particular as anti-alzheimer agents | INSA ROUEN (FR) | 2011-07-12 | — | — | US | disclosed |