Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | CTSA | P10619 | 6/20 | 0.41 |
| ▸ | SUCNR1 | Q9BXA5 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.39 |
| ▸ | PHGDH | O43175 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.38 |
| ▸ | CDK7 | P50613 | 1/20 | 0.38 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.36 |
| ▸ | ITGAV | P06756 | 1/20 | 0.36 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2303540 | 0.88 | KCNA5 (0.43) | PDE4DDYRK1ACDK7ITGB3ITGAV | |
| SCHEMBL14495207 | 0.88 | MAPK1 (0.40) | CTSAFFAR1KEAP1MAPK1 | |
| SCHEMBL14495206 | 0.88 | MAPK1 (0.40) | CTSAFFAR1KEAP1MAPK1 | |
| SCHEMBL13157460 | 0.87 | PDE4D (0.44) | PDE4DDYRK1ACDK7MAPK1 | |
| SCHEMBL27742058 | 0.85 | MAP2K4 (0.38) | PDE4DDYRK1ACDK7 | |
| SCHEMBL2302724 | 0.80 | SLC6A2 (0.44) | DYRK1A | |
| SCHEMBL2301515 | 0.76 | ATM (0.42) | MAPK1 | |
| SCHEMBL14495196 | 0.76 | FFAR1 (0.40) | CTSAFFAR1KEAP1NFE2L2MAPK1 | |
| SCHEMBL13157447 | 0.76 | MAPK1 (0.39) | MAPK1 | |
| SCHEMBL13157449 | 0.76 | MAPK1 (0.39) | MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2351737-A1 | 3-Amino-1-arylpropyl indoles and aza-substituted indoles | F. Hoffmann-La Roche AG (CH) | 2011-08-03 | — | — | EP | disclosed |
| WO-2007062996-A1 | 3-AMINO-1-ARYLPROPYL INDOLES AND AZA-SUBSTITUTED INDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-07 | — | — | WO | disclosed |