Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 17/20 | 0.64 |
| ▸ | CDK1 | P06493 | 4/20 | 0.63 |
| ▸ | CDK2 | P24941 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2357711 | 0.88 | CDK4 (0.78) | CDK4CDK1 | |
| SCHEMBL16627438 | 0.88 | CDK4 (0.77) | CDK4CDK1 | |
| SCHEMBL2363696 | 0.87 | CDK4 (0.76) | CDK4CDK1 | |
| SCHEMBL2363700 | 0.87 | CDK4 (0.76) | CDK4CDK1 | |
| SCHEMBL15012124 | 0.86 | CDK4 (0.82) | CDK4CDK1 | |
| SCHEMBL2363631 | 0.86 | CDK4 (0.82) | CDK4CDK1 | |
| SCHEMBL2302948 | 0.86 | CDK4 (0.81) | CDK4CDK1 | |
| SCHEMBL15012061 | 0.86 | CDK4 (0.81) | CDK4CDK1 | |
| SCHEMBL15012616 | 0.85 | CDK4 (0.82) | CDK4CDK1 | |
| SCHEMBL15032363 | 0.84 | CDK4 (0.75) | CDK4CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2536730-B1 | PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF CDK4/6 | NOVARTIS AG (CH) | 2015-07-08 | — | — | EP | disclosed |
| WO-2011101409-A1 | PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF CDK4/6 | NOVARTIS AG (CH) | 2011-08-25 | — | — | WO | disclosed |