Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 20/20 | 0.58 |
| ▸ | NTRK1 | P04629 | 5/20 | 0.58 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11938856 | 0.92 | IGF1R (0.54) | IGF1RNTRK1FGFR1KDR | |
| SCHEMBL11348597 | 0.89 | IGF1R (0.72) | IGF1RNTRK1 | |
| SCHEMBL11342407 | 0.88 | IGF1R (0.72) | IGF1RNTRK1 | |
| SCHEMBL11348625 | 0.87 | IGF1R (0.68) | IGF1RNTRK1 | |
| SCHEMBL12439842 | 0.85 | IGF1R (0.58) | IGF1RNTRK1 | |
| SCHEMBL12437982 | 0.85 | IGF1R (0.69) | IGF1R | |
| SCHEMBL11349107 | 0.83 | IGF1R (0.70) | IGF1RNTRK1FGFR1KDR | |
| SCHEMBL12439422 | 0.83 | IGF1R (0.66) | IGF1R | |
| SCHEMBL11341969 | 0.83 | IGF1R (0.61) | IGF1RNTRK1 | |
| SCHEMBL11343199 | 0.82 | IGF1R (0.70) | IGF1RNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7999006-B2 | Anticancer agents; mitogen-activated protein kinases (MEK) | EXELIXIS, INC. (US) | 2011-08-16 | — | — | US | disclosed |