Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.69 |
| ▸ | GAA | P10253 | 3/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | RAD52 | P43351 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1241191 | 0.91 | KMT2A (0.75) | MEN1KMT2AGAAKDM4EALDH1A1 | |
| SCHEMBL27656221 | 0.83 | MEN1 (0.73) | MEN1KMT2AGAAKDM4EALDH1A1 | |
| SCHEMBL4110428 | 0.82 | MEN1 (0.79) | MEN1KMT2AGAAKDM4EALDH1A1 | |
| SCHEMBL4111281 | 0.82 | MEN1 (1.00) | MEN1KMT2AGAAKDM4EALDH1A1 | |
| SCHEMBL1243831 | 0.82 | MEN1 (0.85) | MEN1KMT2AGAAKDM4EALDH1A1 | |
| SCHEMBL1243275 | 0.81 | MEN1 (0.68) | MEN1KMT2AGAAKDM4EALDH1A1 | |
| SCHEMBL25069254 | 0.80 | KMT2A (0.78) | MEN1KMT2AGAAKDM4EALDH1A1 | |
| SCHEMBL1243866 | 0.80 | KMT2A (0.81) | MEN1KMT2AGAAKDM4EALDH1A1 | |
| SCHEMBL27635204 | 0.80 | MEN1 (0.71) | MEN1KMT2AGAAKDM4EALDH1A1 | |
| SCHEMBL1243143 | 0.78 | MEN1 (0.56) | MEN1KMT2AGAAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7879878-B2 | such as {2-[({[7-(cyclohexylamino)-6-fluoro-4-oxo-1-[(3S)-tetrahydrofuran-3-yl]-1,4-dihydroquinolin-3-yl}carbonyl)amino]ethyl}phosphonic acid, used as platelet aggregation inhibitor and purinergic receptor (P2Y12) inhibitors; therapy for circulatory diseases involving thrombosis via platelet aggregation | ASTELLAS PHARMA INC. (JP) | 2011-02-01 | — | — | US | disclosed |