Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.61 |
| ▸ | PDE5A | O76074 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.34 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | METAP1 | P53582 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | CLK3 | P49761 | 1/20 | 0.31 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | FASN | P49327 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | FLT1 | P17948 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12430606 | 0.79 | HSP90AB1 (0.80) | HSP90AB1PDE5ASMN1; SMN2HPSEMETAP2 | |
| SCHEMBL12430893 | 0.77 | HSP90AB1 (0.68) | HSP90AB1PDE5ASMN1; SMN2HPSEMETAP2 | |
| SCHEMBL13437165 | 0.77 | HSP90AB1 (0.76) | HSP90AB1PDE5ASMN1; SMN2APLNR | |
| SCHEMBL13437166 | 0.77 | HSP90AB1 (1.00) | HSP90AB1PDE5ASMN1; SMN2HPSEMETAP2 | |
| SCHEMBL13437212 | 0.76 | HSP90AB1 (0.78) | HSP90AB1PDE5ASMN1; SMN2HPSEMETAP2 | |
| SCHEMBL2314870 | 0.76 | HSP90AB1 (0.75) | HSP90AB1PDE5ASMN1; SMN2HPSEMETAP2 | |
| SCHEMBL13437202 | 0.76 | HSP90AB1 (1.00) | HSP90AB1PDE5ASMN1; SMN2HPSEMETAP2 | |
| SCHEMBL13437167 | 0.75 | HSP90AB1 (0.85) | HSP90AB1PDE5ASMN1; SMN2HPSEMETAP2 | |
| SCHEMBL12431194 | 0.75 | HSP90AB1 (0.79) | HSP90AB1PDE5ASMN1; SMN2HPSEMETAP2 | |
| SCHEMBL13437158 | 0.75 | HSP90AB1 (0.75) | HSP90AB1PDE5ASMN1; SMN2HPSEMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1888579-B1 | NOVEL FLUORENE DERIVATIVES, COMPOSITION CONTAINING SAID DERIVATIVES AND THE USE THEREOF | AVENTIS PHARMA SA (FR) | 2011-08-03 | — | — | EP | disclosed |