Sugi Predict

Sugi Predict / Compounds / SCHEMBL12430922

SCHEMBL12430922

SCHEMBL12430922

Cc1cc(C(=O)NC2c3ccccc3-c3c(-c4nc5ccncc5[nH]4)cccc32)cc(Cl)n1

nearest known ligand 0.79

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ HSP90AB1 P08238 5/20 0.79
▸ APLNR P35414 1/20 0.40
▸ PDE5A O76074 3/20 0.40
▸ GPBAR1 Q8TDU6 1/20 0.40
▸ MEN1 O00255 2/20 0.39
▸ KMT2A Q03164 2/20 0.39
▸ HTT P42858 1/20 0.39
▸ LMNA P02545 1/20 0.37
▸ FASN P49327 2/20 0.36
▸ JMJD6 Q6NYC1 1/20 0.36
▸ HPSE Q9Y251 1/20 0.36
▸ SMN1; SMN2 Q16637 2/20 0.35
▸ KDM4E B2RXH2 1/20 0.35
▸ NPC1 O15118 1/20 0.35
▸ ALDH1A1 P00352 1/20 0.35
▸ PKM P14618 1/20 0.35
▸ HPGD P15428 1/20 0.35
▸ RAB9A P51151 1/20 0.35
▸ IRAK4 Q9NWZ3 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12431614 0.91 HSP90AB1 (0.77) HSP90AB1APLNRPDE5AMEN1KMT2A
SCHEMBL13437201 0.91 HSP90AB1 (0.81) HSP90AB1APLNRPDE5AMEN1KMT2A
SCHEMBL13437166 0.88 HSP90AB1 (1.00) HSP90AB1APLNRPDE5AMEN1KMT2A
SCHEMBL12430606 0.85 HSP90AB1 (0.80) HSP90AB1APLNRPDE5AJMJD6HPSE
SCHEMBL13437167 0.85 HSP90AB1 (0.85) HSP90AB1APLNRPDE5AMEN1KMT2A
SCHEMBL13437169 0.84 HSP90AB1 (0.81) HSP90AB1APLNRPDE5AMEN1KMT2A
SCHEMBL12430894 0.84 HSP90AB1 (0.78) HSP90AB1APLNRPDE5AMEN1KMT2A
SCHEMBL13437214 0.84 HSP90AB1 (0.79) HSP90AB1APLNRPDE5AIRAK4
SCHEMBL13437209 0.84 HSP90AB1 (0.81) HSP90AB1APLNRPDE5AMEN1KMT2A
SCHEMBL13437204 0.84 HSP90AB1 (0.81) HSP90AB1APLNRPDE5AHPSESMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1888579-B1 NOVEL FLUORENE DERIVATIVES, COMPOSITION CONTAINING SAID DERIVATIVES AND THE USE THEREOF AVENTIS PHARMA SA (FR) 2011-08-03 — — EP disclosed
US-7674795-B2 Fluorene derivatives, composition containing said derivatives and the use thereof AVENTIS PHARMA SA (FR) 2010-03-09 — — US disclosed
US-7674795-B2 Fluorene derivatives, composition containing said derivatives and the use thereof AVENTIS PHARMA SA (FR) 2010-03-09 — — US disclosed
US-20080153837-A1 Novel Fluorene Derivatives, Composition Containing Said Derivatives and the Use Thereof AVENTIS PHARMA S.A. (FR) 2008-06-26 — — US disclosed
US-20080153837-A1 Novel Fluorene Derivatives, Composition Containing Said Derivatives and the Use Thereof AVENTIS PHARMA S.A. (FR) 2008-06-26 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080153837-A1 Novel Fluorene Derivatives, Composition Containing Said Derivatives and the Use Thereof HSP90B1, HSP90AB1, HSP90AA1 HSP90AB1 2/4885APLNR 4791/4885PDE5A 2779/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.