Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 8/20 | 0.54 |
| ▸ | LNPEP | Q9UIQ6 | 4/20 | 0.42 |
| ▸ | HRH2 | P25021 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | ERAP2 | Q6P179 | 3/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1391452 | 0.89 | AAK1 (0.53) | AAK1LNPEPERAP2 | |
| SCHEMBL1391454 | 0.89 | AAK1 (0.53) | AAK1LNPEPERAP2 | |
| SCHEMBL12432823 | 0.87 | HRH2 (0.42) | AAK1HRH2HRH1JAK2 | |
| SCHEMBL12432828 | 0.84 | HRH2 (0.42) | AAK1HRH2HRH1JAK2 | |
| SCHEMBL9286086 | 0.81 | AAK1 (0.51) | AAK1JAK2HDAC2 | |
| SCHEMBL9283981 | 0.81 | AAK1 (0.51) | AAK1JAK2HDAC2 | |
| SCHEMBL2509375 | 0.79 | AAK1 (0.49) | AAK1JAK2 | |
| SCHEMBL2509377 | 0.79 | AAK1 (0.49) | AAK1JAK2 | |
| SCHEMBL22078572 | 0.77 | AAK1 (0.53) | AAK1JAK2 | |
| SCHEMBL23754447 | 0.76 | PPARG (0.45) | AAK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2351743-A1 | BICYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-08-03 | — | — | EP | disclosed |