Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.55 |
| ▸ | MAPT | P10636 | 7/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.55 |
| ▸ | BLM | P54132 | 3/20 | 0.55 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.55 |
| ▸ | GAA | P10253 | 4/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.49 |
| ▸ | CASP7 | P55210 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | THPO | P40225 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26077191 | 0.80 | KDM4E (0.51) | KDM4EMAPTALDH1A1HSD17B10LMNA | |
| SCHEMBL1390919 | 0.78 | TSHR (0.53) | KDM4EMAPTALDH1A1LMNAHPGD | |
| SCHEMBL1390768 | 0.78 | CA9 (0.49) | KDM4EMAPTALDH1A1HSD17B10LMNA | |
| SCHEMBL12432354 | 0.78 | MAPT (0.53) | KDM4EMAPTALDH1A1HSD17B10LMNA | |
| SCHEMBL12432332 | 0.77 | MAPT (0.49) | KDM4EMAPTALDH1A1HSD17B10LMNA | |
| SCHEMBL1390502 | 0.76 | CA9 (0.48) | KDM4EALDH1A1LMNAHIF1AGAA | |
| SCHEMBL1390533 | 0.76 | CA9 (0.51) | MAPTALDH1A1LMNAHPGDGAA | |
| SCHEMBL1390775 | 0.76 | PIM1 (0.49) | KDM4EALDH1A1HSD17B10LMNAHPGD | |
| SCHEMBL4507247 | 0.76 | KDM4E (0.74) | KDM4EMAPTALDH1A1HSD17B10LMNA | |
| SCHEMBL1390658 | 0.75 | SMN1; SMN2 (0.47) | KDM4EMAPTALDH1A1HSD17B10LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2351743-A1 | BICYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-08-03 | — | — | EP | disclosed |