Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMO | Q99835 | 5/20 | 0.55 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.55 |
| ▸ | KDR | P35968 | 5/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 2/20 | 0.51 |
| ▸ | CKS1B | P61024 | 1/20 | 0.51 |
| ▸ | SKP1 | P63208 | 1/20 | 0.51 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1268247 | 0.99 | SMO (0.55) | SMOPAK1KDRHTTNPSR1 | |
| SCHEMBL12435117 | 0.93 | SMO (0.54) | SMOPAK1KDRHTTNPSR1 | |
| Hydrochloric Acid SCHEMBL2205497 | 0.92 | SMO (0.53) | SMOPAK1KDRHTTNPSR1 | |
| SCHEMBL12435127 | 0.90 | SMO (0.61) | SMOKDRHTTNPSR1CKS1B | |
| SCHEMBL4257505 | 0.90 | SMO (0.57) | SMOKDRHTTNPSR1MEN1 | |
| SCHEMBL12435101 | 0.85 | SMO (0.65) | SMOPAK1KDRHTTNPSR1 | |
| Hydrochloric Acid SCHEMBL1268376 | 0.84 | SMO (0.64) | SMOPAK1KDRHTTNPSR1 | |
| SCHEMBL27809326 | 0.82 | CKS1B (0.53) | SMOKDRHTTNPSR1CKS1B | |
| Hydrochloric Acid SCHEMBL1268477 | 0.80 | NPSR1 (0.54) | SMOKDRHTTNPSR1MEN1 | |
| Isophthalic Acid SCHEMBL28790907 | 0.79 | SMO (0.57) | SMOKDRHTTNPSR1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7981892-B2 | Disubstituted phthalazine hedgehog pathway antagonists | ELI LILLY AND COMPANY (US) | 2011-07-19 | — | — | US | disclosed |
| US-7981892-B2 | Disubstituted phthalazine hedgehog pathway antagonists | ELI LILLY AND COMPANY (US) | 2011-07-19 | — | — | US | disclosed |
| US-20110046143-A1 | DISUBSTITUTED PHTHALAZINE HEDGEHOG PATHWAY ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-02-24 | — | — | US | disclosed |
| US-20110046143-A1 | DISUBSTITUTED PHTHALAZINE HEDGEHOG PATHWAY ANTAGONISTS | ELI LILLY AND COMPANY (US) | 2011-02-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110046143-A1 | DISUBSTITUTED PHTHALAZINE HEDGEHOG PATHWAY ANTAGONISTS | SHH, GLI1, SMO | SMO 3/4885PAK1 585/4885KDR 1085/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.