Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 8/20 | 0.50 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | BRD2 | P25440 | 1/20 | 0.45 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.45 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 4/20 | 0.44 |
| ▸ | SYK | P43405 | 4/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | STK4 | Q13043 | 1/20 | 0.43 |
| ▸ | STK3 | Q13188 | 1/20 | 0.43 |
| ▸ | BMPR2 | Q13873 | 1/20 | 0.43 |
| ▸ | STK26 | Q9P289 | 1/20 | 0.43 |
| ▸ | STK24 | Q9Y6E0 | 1/20 | 0.43 |
| ▸ | ZAP70 | P43403 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2158052 | 0.87 | NEK1 (0.53) | IGF1RNEK1SRCAKT1TGFBR1 | |
| SCHEMBL18901334 | 0.86 | IGF1R (0.53) | IGF1RNEK1KDRFGFR1SRC | |
| SCHEMBL12785351 | 0.86 | NEK1 (0.66) | IGF1RNEK1FGFR1SRCAKT1 | |
| SCHEMBL11348830 | 0.86 | IGF1R (0.69) | IGF1RNEK1KDRFGFR1SRC | |
| SCHEMBL2158172 | 0.85 | NEK1 (0.54) | IGF1RNEK1FGFR1SRCSYK | |
| SCHEMBL11344820 | 0.84 | IGF1R (0.66) | IGF1R | |
| SCHEMBL14050460 | 0.84 | IGF1R (0.50) | IGF1RNEK1KDRFGFR1SRC | |
| SCHEMBL11342663 | 0.84 | IGF1R (0.69) | IGF1RNEK1SRCAKT1TGFBR1 | |
| SCHEMBL12045459 | 0.83 | SRC (0.57) | IGF1RNEK1SRCSYK | |
| SCHEMBL11410231 | 0.82 | IGF1R (0.54) | IGF1RNEK1KDRFGFR1SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841760-B1 | PYRIMIDINE DERIVATIVES AS KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2011-08-10 | — | — | EP | disclosed |
| WO-2008127594-A2 | COMBINATION THERAPIES COMPRISING QUINOXALINE INHIBITORS OF PI3K-ALPHA FOR USE IN THE TREATMENT OF CANCER | EXELIXIS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |
| WO-2008005538-A2 | METHODS OF USING IGF1R AND ABL KINASE MODULATORS | EXELIXIS, INC. (US) | 2008-01-10 | — | — | WO | disclosed |