Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 17/20 | 0.85 |
| ▸ | INSR | P06213 | 7/20 | 0.70 |
| ▸ | LYN | P07948 | 5/20 | 0.70 |
| ▸ | SRC | P12931 | 4/20 | 0.70 |
| ▸ | LCK | P06239 | 4/20 | 0.70 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.70 |
| ▸ | KDR | P35968 | 4/20 | 0.70 |
| ▸ | FLT3 | P36888 | 4/20 | 0.70 |
| ▸ | EGFR | P00533 | 4/20 | 0.70 |
| ▸ | FLT4 | P35916 | 3/20 | 0.70 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.70 |
| ▸ | KIT | P10721 | 3/20 | 0.70 |
| ▸ | FLT1 | P17948 | 3/20 | 0.70 |
| ▸ | RET | P07949 | 3/20 | 0.70 |
| ▸ | CSF1R | P07333 | 3/20 | 0.70 |
| ▸ | BLK | P51451 | 3/20 | 0.70 |
| ▸ | ERBB4 | Q15303 | 2/20 | 0.70 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.70 |
| ▸ | AURKA | O14965 | 2/20 | 0.70 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1984101 | 0.92 | IGF1R (1.00) | IGF1RINSRLYNSRCLCK | |
| SCHEMBL1983400 | 0.92 | IGF1R (1.00) | IGF1RINSRLYNSRCLCK | |
| SCHEMBL1983399 | 0.92 | IGF1R (1.00) | IGF1RINSRLYNSRCLCK | |
| SCHEMBL1986302 | 0.90 | IGF1R (0.87) | IGF1RINSRLYNSRCLCK | |
| SCHEMBL1985881 | 0.90 | IGF1R (0.87) | IGF1RINSRLYNSRCLCK | |
| SCHEMBL1985882 | 0.90 | IGF1R (0.87) | IGF1RINSRLYNSRCLCK | |
| SCHEMBL1985479 | 0.90 | IGF1R (0.81) | IGF1RINSRLYNSRCLCK | |
| SCHEMBL1984360 | 0.90 | IGF1R (0.81) | IGF1RINSRLYNSRCLCK | |
| SCHEMBL1990741 | 0.90 | IGF1R (0.87) | IGF1RINSRLYNSRCLCK | |
| SCHEMBL1985909 | 0.90 | IGF1R (0.87) | IGF1RINSRLYNSRCLCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2139483-B9 | COMBINATION THERAPIES COMPRISING A QUINOXALINE INHIBITOR OF PI3K-ALPHA FOR USE IN THE TREATMENT OF CANCER | EXELIXIS INC (US) | 2014-05-21 | — | — | EP | disclosed |
| EP-2139483-B1 | COMBINATION THERAPIES COMPRISING A QUINOXALINE INHIBITOR OF PI3K-ALPHA FOR USE IN THE TREATMENT OF CANCER | EXELIXIS INC (US) | 2013-09-18 | — | — | EP | disclosed |
| EP-1841760-B1 | PYRIMIDINE DERIVATIVES AS KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2011-08-10 | — | — | EP | disclosed |
| WO-2008127594-A2 | COMBINATION THERAPIES COMPRISING QUINOXALINE INHIBITORS OF PI3K-ALPHA FOR USE IN THE TREATMENT OF CANCER | EXELIXIS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |
| WO-2008076415-A1 | METHODS OF USING MEK INHIBITORS | EXELIXIS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008005538-A2 | METHODS OF USING IGF1R AND ABL KINASE MODULATORS | EXELIXIS, INC. (US) | 2008-01-10 | — | — | WO | disclosed |