Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 9/20 | 0.59 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.46 |
| ▸ | GSK3B | P49841 | 4/20 | 0.45 |
| ▸ | PLK1 | P53350 | 2/20 | 0.42 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 3/20 | 0.41 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.40 |
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | DCLK1 | O15075 | 1/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.40 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11348892 | 0.90 | IGF1R (0.73) | IGF1RGSK3BGSK3APRKCQDCLK1 | |
| SCHEMBL12439767 | 0.86 | IGF1R (0.58) | IGF1RLRRK2CDK2CDK5 | |
| SCHEMBL12437982 | 0.84 | IGF1R (0.69) | IGF1R | |
| SCHEMBL11938857 | 0.84 | IGF1R (0.56) | IGF1RLRRK2CDK2CDK5 | |
| SCHEMBL11342483 | 0.83 | IGF1R (0.59) | IGF1RGSK3BGSK3APRKCQMAPT | |
| SCHEMBL14161874 | 0.83 | IGF1R (0.53) | IGF1RLRRK2AURKA | |
| SCHEMBL12438227 | 0.81 | IGF1R (0.49) | IGF1RALKLRRK2MET | |
| SCHEMBL14050613 | 0.81 | IGF1R (0.51) | IGF1RLRRK2CDK2CDK5 | |
| SCHEMBL12439422 | 0.80 | IGF1R (0.66) | IGF1R | |
| SCHEMBL14050422 | 0.79 | IGF1R (0.65) | IGF1RMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841760-B1 | PYRIMIDINE DERIVATIVES AS KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2011-08-10 | — | — | EP | disclosed |
| WO-2008127594-A2 | COMBINATION THERAPIES COMPRISING QUINOXALINE INHIBITORS OF PI3K-ALPHA FOR USE IN THE TREATMENT OF CANCER | EXELIXIS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |
| WO-2008076415-A1 | METHODS OF USING MEK INHIBITORS | EXELIXIS, INC. (US) | 2008-06-26 | — | — | WO | disclosed |
| WO-2008005538-A2 | METHODS OF USING IGF1R AND ABL KINASE MODULATORS | EXELIXIS, INC. (US) | 2008-01-10 | — | — | WO | disclosed |