Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 20/20 | 0.84 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.61 |
| ▸ | KDR | P35968 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11341645 | 0.91 | IGF1R (1.00) | IGF1R | |
| SCHEMBL14050663 | 0.91 | IGF1R (0.84) | IGF1RFGFR1KDR | |
| SCHEMBL11349367 | 0.89 | IGF1R (1.00) | IGF1RFGFR1KDR | |
| SCHEMBL4305959 | 0.83 | IGF1R (1.00) | IGF1RFGFR1KDR | |
| SCHEMBL4011011 | 0.81 | IGF1R (1.00) | IGF1RFGFR1 | |
| SCHEMBL11340066 | 0.80 | IGF1R (1.00) | IGF1R | |
| SCHEMBL4012244 | 0.80 | IGF1R (0.78) | IGF1RFGFR1KDR | |
| SCHEMBL2318459 | 0.79 | IGF1R (1.00) | IGF1R | |
| SCHEMBL15256330 | 0.79 | IGF1R (0.87) | IGF1R | |
| SCHEMBL4564747 | 0.79 | IGF1R (1.00) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841760-B1 | PYRIMIDINE DERIVATIVES AS KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2011-08-10 | — | — | EP | disclosed |