Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 18/20 | 0.60 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4470599 | 0.92 | IGF1R (0.72) | IGF1RCDK19ALKSYK | |
| SCHEMBL11339007 | 0.88 | IGF1R (0.69) | IGF1RSYK | |
| SCHEMBL15109602 | 0.87 | SYK (0.65) | IGF1RSYK | |
| SCHEMBL11345813 | 0.85 | IGF1R (0.71) | IGF1RSYK | |
| SCHEMBL14050601 | 0.85 | IGF1R (0.62) | IGF1RCDK19ALK | |
| SCHEMBL11938447 | 0.85 | IGF1R (0.56) | IGF1RSYK | |
| SCHEMBL4466607 | 0.83 | IGF1R (0.70) | IGF1RSYK | |
| SCHEMBL11342893 | 0.82 | IGF1R (0.75) | IGF1RCDK19ALK | |
| SCHEMBL11340156 | 0.82 | IGF1R (0.71) | IGF1RSYK | |
| SCHEMBL15580718 | 0.82 | IGF1R (0.58) | IGF1RSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841760-B1 | PYRIMIDINE DERIVATIVES AS KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2011-08-10 | — | — | EP | disclosed |
| WO-2008127594-A2 | COMBINATION THERAPIES COMPRISING QUINOXALINE INHIBITORS OF PI3K-ALPHA FOR USE IN THE TREATMENT OF CANCER | EXELIXIS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |