Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 20/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4456951 | 0.89 | IGF1R (0.73) | IGF1R | |
| SCHEMBL4466607 | 0.88 | IGF1R (0.70) | IGF1R | |
| SCHEMBL4459141 | 0.87 | IGF1R (0.74) | IGF1R | |
| SCHEMBL11345387 | 0.85 | IGF1R (0.75) | IGF1R | |
| SCHEMBL11339853 | 0.85 | IGF1R (0.68) | IGF1R | |
| SCHEMBL11938849 | 0.85 | IGF1R (0.57) | IGF1R | |
| SCHEMBL11339784 | 0.84 | IGF1R (0.74) | IGF1R | |
| SCHEMBL11345245 | 0.83 | IGF1R (0.69) | IGF1R | |
| SCHEMBL4456905 | 0.83 | IGF1R (0.70) | IGF1R | |
| SCHEMBL4462586 | 0.83 | IGF1R (0.76) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841760-B1 | PYRIMIDINE DERIVATIVES AS KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2011-08-10 | — | — | EP | disclosed |
| WO-2008127594-A2 | COMBINATION THERAPIES COMPRISING QUINOXALINE INHIBITORS OF PI3K-ALPHA FOR USE IN THE TREATMENT OF CANCER | EXELIXIS, INC. (US) | 2008-10-23 | — | — | WO | disclosed |