Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 9/20 | 0.59 |
| ▸ | CHRM5 | P08912 | 9/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 9/20 | 0.59 |
| ▸ | CHRM3 | P20309 | 8/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 7/20 | 0.59 |
| ▸ | CBX7 | O95931 | 2/20 | 0.40 |
| ▸ | CDYL2 | Q8N8U2 | 2/20 | 0.40 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 2/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.40 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | CLK1 | P49759 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2218018 | 1.00 | CHRM4 (0.59) | CHRM4CHRM5CHRM1CHRM3CHRM2 | |
| SCHEMBL2220699 | 1.00 | CHRM4 (0.59) | CHRM4CHRM5CHRM1CHRM3CHRM2 | |
| SCHEMBL2218014 | 1.00 | CHRM4 (0.59) | CHRM4CHRM5CHRM1CHRM3CHRM2 | |
| Hydrochloric Acid SCHEMBL2217254 | 0.99 | CHRM4 (0.58) | CHRM4CHRM5CHRM1CHRM3CHRM2 | |
| Hydrochloric Acid SCHEMBL2217251 | 0.99 | CHRM4 (0.58) | CHRM4CHRM5CHRM1CHRM3CHRM2 | |
| Hydrochloric Acid SCHEMBL2220554 | 0.99 | CHRM4 (0.58) | CHRM4CHRM5CHRM1CHRM3CHRM2 | |
| SCHEMBL12514349 | 0.86 | CHRM4 (0.53) | CHRM4CHRM5CHRM1CHRM3CHRM2 | |
| SCHEMBL2229097 | 0.83 | CHRM4 (0.51) | CHRM4CHRM5CHRM1CBX7CDYL2 | |
| SCHEMBL8058738 | 0.77 | CHRM2 (0.56) | CHRM4CHRM5CHRM1CHRM3CHRM2 | |
| SCHEMBL8067487 | 0.76 | CHRM2 (0.55) | CHRM4CHRM5CHRM1CHRM3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2344483-B1 | COMPOUNDS WHICH HAVE ACTIVITY AT M1 RECEPTOR AND THEIR USES IN MEDICINE | GLAXOSMITHKLINE IP DEV LTD (GB) | 2013-05-01 | — | — | EP | claimed |
| US-20110178131-A1 | Compounds Which Have Activity At M1 Receptor And Their Uses In Medicine | GLAXO GROUP LIMITED (GB) | 2011-07-21 | — | — | US | disclosed |
| US-20110178131-A1 | Compounds Which Have Activity At M1 Receptor And Their Uses In Medicine | GLAXO GROUP LIMITED (GB) | 2011-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178131-A1 | Compounds Which Have Activity At M1 Receptor And Their Uses In Medicine | CHRM1, CHRM2, CHRM5 | CHRM4 4/4885CHRM5 3/4885CHRM1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.