Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IGF1R | P08069 | 20/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12439431 | 0.94 | IGF1R (0.68) | IGF1R | |
| SCHEMBL12439394 | 0.81 | IGF1R (0.57) | IGF1R | |
| SCHEMBL4457289 | 0.81 | IGF1R (1.00) | IGF1R | |
| SCHEMBL3931935 | 0.77 | IGF1R (1.00) | IGF1R | |
| SCHEMBL12439820 | 0.77 | IGF1R (0.58) | IGF1R | |
| SCHEMBL4459986 | 0.75 | IGF1R (1.00) | IGF1R | |
| SCHEMBL4011707 | 0.72 | IGF1R (1.00) | IGF1R | |
| SCHEMBL15580740 | 0.71 | IGF1R (0.40) | IGF1R | |
| SCHEMBL14311612 | 0.71 | IGF1R (0.59) | IGF1R | |
| SCHEMBL1791561 | 0.70 | IGF1R (0.67) | IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841760-B1 | PYRIMIDINE DERIVATIVES AS KINASE MODULATORS AND METHOD OF USE | EXELIXIS INC (US) | 2011-08-10 | — | — | EP | disclosed |
| WO-2008005538-A2 | METHODS OF USING IGF1R AND ABL KINASE MODULATORS | EXELIXIS, INC. (US) | 2008-01-10 | — | — | WO | disclosed |