Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16230108 | 1.00 | NR1I2 (0.52) | NR1I2CYP2E1 | |
| SCHEMBL2216863 | 1.00 | NR1I2 (0.52) | NR1I2CYP2E1 | |
| SCHEMBL16661931 | 0.89 | NR1I2 (0.38) | NR1I2CYP2E1 | |
| SCHEMBL12439442 | 0.88 | NR1I2 (0.54) | NR1I2CYP2E1 | |
| SCHEMBL2218405 | 0.88 | NR1I2 (0.53) | NR1I2CYP2E1 | |
| SCHEMBL12439519 | 0.88 | NR1I2 (0.56) | NR1I2CYP2E1 | |
| SCHEMBL2216701 | 0.88 | NR1I2 (0.53) | NR1I2CYP2E1 | |
| SCHEMBL2220211 | 0.87 | CYP2E1 (0.54) | NR1I2CYP2E1 | |
| SCHEMBL2224140 | 0.86 | NR1I2 (0.57) | NR1I2CYP2E1 | |
| SCHEMBL2220558 | 0.86 | NR1I2 (0.57) | NR1I2CYP2E1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2523951-B1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES INC (US) | 2015-04-22 | — | — | EP | disclosed |
| US-8884030-B2 | Inhibitors of Flaviviridae viruses | GILEAD SCIENCES, INC. (US) | 2014-11-11 | — | — | US | disclosed |
| US-8884030-B2 | Inhibitors of Flaviviridae viruses | GILEAD SCIENCES, INC. (US) | 2014-11-11 | — | — | US | disclosed |
| US-8524764-B2 | Inhibitors of Flaviviridae viruses | GILEAD SCIENCES, INC. (US) | 2013-09-03 | — | — | US | disclosed |
| US-8524764-B2 | Inhibitors of Flaviviridae viruses | GILEAD SCIENCES, INC. (US) | 2013-09-03 | — | — | US | disclosed |
| US-20110178058-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES, INC. (US) | 2011-07-21 | — | — | US | disclosed |
| US-20110178058-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | GILEAD SCIENCES, INC. (US) | 2011-07-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110178058-A1 | INHIBITORS OF FLAVIVIRIDAE VIRUSES | HAVCR2, CYP2F1, CYP4F3 | NR1I2 88/4885CYP2E1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.