Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K7 | O43318 | 8/20 | 0.50 |
| ▸ | TAB1 | Q15750 | 8/20 | 0.50 |
| ▸ | MAP4K3 | Q8IVH8 | 5/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.45 |
| ▸ | MET | P08581 | 4/20 | 0.43 |
| ▸ | GRK2 | P25098 | 1/20 | 0.43 |
| ▸ | GRK5 | P34947 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | ACVRL1 | P37023 | 3/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL659096 | 0.82 | MAP3K7 (0.66) | MAP3K7TAB1MAP4K3METGRK2 | |
| SCHEMBL10217357 | 0.82 | MAP3K7 (0.71) | MAP3K7TAB1MAP4K3AURKBMET | |
| Hydrochloric Acid SCHEMBL659849 | 0.81 | MAP3K7 (0.65) | MAP3K7TAB1MAP4K3METGRK2 | |
| Hydrochloric Acid SCHEMBL658840 | 0.81 | MAP3K7 (0.70) | MAP3K7TAB1MAP4K3AURKBMET | |
| SCHEMBL12443769 | 0.75 | MAP3K7 (0.59) | MAP3K7TAB1AURKBKDR | |
| SCHEMBL10217366 | 0.74 | GRK5 (0.59) | MAP3K7TAB1MAP4K3METGRK2 | |
| SCHEMBL12444634 | 0.74 | MAP3K7 (0.68) | MAP3K7TAB1MAP4K3AURKBKDR | |
| Hydrochloric Acid SCHEMBL660282 | 0.74 | GRK5 (0.58) | MAP3K7TAB1MAP4K3METGRK2 | |
| SCHEMBL10217380 | 0.73 | MAP3K7 (0.66) | MAP3K7TAB1MAP4K3AURKBMET | |
| Hydrochloric Acid SCHEMBL659954 | 0.73 | MAP3K7 (0.65) | MAP3K7TAB1MAP4K3AURKBMET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011100502-A1 | 7-AMINOFUROPYRIDINE DERIVATIVES | OSI Pharmaceuticals, LLC (US) | 2011-08-18 | — | — | WO | disclosed |