SCHEMBL12445298

SCHEMBL12445298

CC(C)(C)OC(=O)N1CC(F)(F)C(F)(F)C1

nearest known ligand 0.48

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
USP2 O75604 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
NR1H2 P55055 2/20 0.42
HPGD P15428 1/20 0.41
EPHX2 P34913 1/20 0.41
RECQL P46063 1/20 0.39
EPHX1 P07099 1/20 0.39
DDB1 Q16531 1/20 0.38
CRBN Q96SW2 1/20 0.38
CHRM2 P08172 1/20 0.38
CHRM1 P11229 1/20 0.38
CHRM3 P20309 1/20 0.38
HTT P42858 1/20 0.37
ATM Q13315 1/20 0.37
GPR119 Q8TDV5 1/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12384327 0.88 USP2 (0.48) USP2SMN1; SMN2NR1H2HPGDEPHX2
SCHEMBL31190819 0.87 USP2 (0.42) USP2SMN1; SMN2NR1H2HPGDEPHX2
SCHEMBL12445300 0.87 USP2 (0.46) USP2SMN1; SMN2HPGDEPHX2RECQL
SCHEMBL21098079 0.86 USP2 (0.47) USP2SMN1; SMN2NR1H2HPGDEPHX2
SCHEMBL29021755 0.83 USP2 (0.42) USP2SMN1; SMN2NR1H2HPGDEPHX2
SCHEMBL31190652 0.83 USP2 (0.42) USP2SMN1; SMN2NR1H2HPGDEPHX2
SCHEMBL31184583 0.83 USP2 (0.42) USP2SMN1; SMN2NR1H2HPGDEPHX2
SCHEMBL22983828 0.83 USP2 (0.39) USP2SMN1; SMN2NR1H2HPGDEPHX2
SCHEMBL30918959 0.83 NR1H2 (0.39) USP2SMN1; SMN2NR1H2HPGDEPHX2
SCHEMBL22983381 0.83 NR1H2 (0.41) USP2SMN1; SMN2NR1H2HPGDEPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2348010-B1 METHOD FOR PRODUCING TETRAFLUORO COMPOUND NIPPON SODA CO (JP) 2014-02-26 EP disclosed
US-8481774-B2 Method for producing tetrafluoro compound NIPPON SODA CO., LTD. (JP) 2013-07-09 US disclosed
US-8481774-B2 Method for producing tetrafluoro compound NIPPON SODA CO., LTD. (JP) 2013-07-09 US disclosed
EP-2348010-A1 METHOD FOR PRODUCING TETRAFLUORO COMPOUND Nippon Soda Co., Ltd. (JP) 2011-07-27 EP disclosed
US-20110178323-A1 METHOD FOR PRODUCING TETRAFLUORO COMPOUND NIPPON SODA CO., LTD. (JP) 2011-07-21 US disclosed
US-20110178323-A1 METHOD FOR PRODUCING TETRAFLUORO COMPOUND NIPPON SODA CO., LTD. (JP) 2011-07-21 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110178323-A1 METHOD FOR PRODUCING TETRAFLUORO COMPOUND F9, CA9, TAF9 USP2 4138/4885SMN1; SMN2 3613/4885NR1H2 3764/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.