Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 19/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL287106 | 0.89 | BACE1 (0.70) | BACE1APP | |
| SCHEMBL12445803 | 0.85 | BACE1 (0.64) | BACE1 | |
| SCHEMBL12446190 | 0.85 | BACE1 (0.58) | BACE1APP | |
| SCHEMBL12445773 | 0.83 | BACE1 (0.50) | BACE1 | |
| SCHEMBL12446182 | 0.83 | BACE1 (0.56) | BACE1 | |
| SCHEMBL12446188 | 0.83 | BACE1 (0.65) | BACE1 | |
| SCHEMBL12446197 | 0.82 | GLA (0.52) | BACE1 | |
| SCHEMBL7941420 | 0.82 | BACE1 (0.84) | BACE1 | |
| SCHEMBL287115 | 0.82 | BACE1 (0.84) | BACE1 | |
| SCHEMBL12446186 | 0.82 | BACE1 (0.64) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2360155-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2011-08-24 | — | — | EP | disclosed |