Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12301420 | 0.76 | BACE1 (0.49) | BACE1 | |
| SCHEMBL7944645 | 0.76 | BACE1 (0.61) | BACE1 | |
| SCHEMBL12301738 | 0.75 | NPC1 (0.49) | — | |
| SCHEMBL7940952 | 0.75 | BACE1 (0.43) | BACE1 | |
| SCHEMBL7940429 | 0.75 | BACE1 (0.44) | BACE1 | |
| SCHEMBL7942132 | 0.74 | BACE1 (0.52) | BACE1 | |
| SCHEMBL7943453 | 0.74 | BACE1 (0.51) | BACE1 | |
| SCHEMBL7934650 | 0.74 | BACE1 (0.53) | BACE1 | |
| SCHEMBL7941989 | 0.74 | BACE1 (0.57) | BACE1 | |
| SCHEMBL7944990 | 0.74 | BACE1 (0.50) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2360155-A1 | 2-AMINOPYRIDIN-4-ONE AND 2-AMINOPYRIDINE DERIVATIVE BOTH HAVING BACE1-INHIBITING ACTIVITY | Shionogi & Co., Ltd. (JP) | 2011-08-24 | — | — | EP | disclosed |