Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 2/20 | 0.44 |
| ▸ | CCR5 | P51681 | 16/20 | 0.43 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2337903 | 1.00 | OPRL1 (0.44) | OPRL1CCR5P2RX7DRD2HTR2A | |
| SCHEMBL2337906 | 1.00 | OPRL1 (0.44) | OPRL1CCR5P2RX7DRD2HTR2A | |
| Hydrochloric Acid SCHEMBL2340066 | 0.99 | OPRL1 (0.44) | OPRL1CCR5P2RX7DRD2HTR2A | |
| Hydrochloric Acid SCHEMBL2340065 | 0.99 | OPRL1 (0.44) | OPRL1CCR5P2RX7DRD2HTR2A | |
| SCHEMBL2338555 | 0.94 | OPRL1 (0.47) | OPRL1CCR5DRD2HTR2AHTR2C | |
| SCHEMBL2338553 | 0.94 | OPRL1 (0.47) | OPRL1CCR5DRD2HTR2AHTR2C | |
| SCHEMBL14371426 | 0.94 | OPRL1 (0.47) | OPRL1CCR5DRD2HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL2342001 | 0.93 | OPRL1 (0.47) | OPRL1CCR5DRD2HTR2AHTR2C | |
| Hydrochloric Acid SCHEMBL2342005 | 0.93 | OPRL1 (0.47) | OPRL1CCR5DRD2HTR2AHTR2C | |
| SCHEMBL2335931 | 0.90 | OPRL1 (0.46) | OPRL1CCR5DRD2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1786815-B1 | SPIRO COMPOUNDS AND METHODS FOR THE MODULATION OF CHEMOKINE RECEPTOR ACTIVITY | VIROCHEM PHARMA INC (CA) | 2011-08-24 | — | — | EP | disclosed |
| US-7288548-B2 | Spiro compounds and methods for the modulation of chemokine receptor activity | VIROCHEM PHARMA, INC. (CA) | 2007-10-30 | — | — | US | disclosed |
| US-7288548-B2 | Spiro compounds and methods for the modulation of chemokine receptor activity | VIROCHEM PHARMA, INC. (CA) | 2007-10-30 | — | — | US | disclosed |