Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 9/20 | 0.66 |
| ▸ | FGFR3 | P22607 | 9/20 | 0.66 |
| ▸ | CDK8 | P49336 | 1/20 | 0.52 |
| ▸ | FYN | P06241 | 4/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.51 |
| ▸ | KIT | P10721 | 2/20 | 0.51 |
| ▸ | FLT3 | P36888 | 2/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL837839 | 0.87 | FGFR1 (0.65) | FGFR1FGFR3CDK8FYNNTRK1 | |
| SCHEMBL835840 | 0.81 | FGFR3 (0.73) | FGFR1FGFR3CDK8FYNNTRK1 | |
| SCHEMBL834829 | 0.80 | FGFR1 (0.70) | FGFR1FGFR3CDK8FYNNTRK1 | |
| SCHEMBL837206 | 0.80 | FGFR3 (0.70) | FGFR1FGFR3CDK8FYNNTRK1 | |
| SCHEMBL837898 | 0.78 | CDK8 (0.55) | FGFR1FGFR3CDK8FYNNTRK1 | |
| SCHEMBL837301 | 0.77 | FGFR3 (0.67) | FGFR1FGFR3CDK8FYNNTRK1 | |
| SCHEMBL836898 | 0.77 | FGFR3 (0.67) | FGFR1FGFR3CDK8FYNNTRK1 | |
| SCHEMBL2340954 | 0.77 | FGFR3 (0.66) | FGFR1FGFR3CDK8FYNNTRK1 | |
| SCHEMBL835499 | 0.77 | FGFR3 (0.66) | FGFR1FGFR3FYNNTRK1PDGFRB | |
| SCHEMBL836782 | 0.76 | FGFR1 (0.65) | FGFR1FGFR3CDK8FYNNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183027-B1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2011-08-31 | — | — | EP | disclosed |
| WO-2009013335-A1 | ORGANIC COMPOUNDS | NOVARTIS AG (CH) | 2009-01-29 | — | — | WO | disclosed |