Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.39 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MC4R | P32245 | 4/20 | 0.35 |
| ▸ | MC3R | P41968 | 4/20 | 0.35 |
| ▸ | MC5R | P33032 | 3/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.34 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12449224 | 0.84 | ROCK1 (0.38) | ROCK1LIMK2CYP3A4MC4RMC3R | |
| SCHEMBL12449779 | 0.81 | MC3R (0.39) | MAPTROCK1LIMK2KDM4EALDH1A1 | |
| SCHEMBL10098875 | 0.80 | TAAR1 (0.47) | ROCK1HDAC1HDAC8 | |
| SCHEMBL12156519 | 0.77 | LIMK2 (0.62) | ROCK1LIMK2KDM4ECYP3A4TDP1 | |
| SCHEMBL10098876 | 0.77 | TAAR1 (0.47) | MAPTCYP3A4TSHRCARM1 | |
| SCHEMBL12449381 | 0.77 | PTPRZ1 (0.43) | MAPTROCK1LIMK2KDM4EALDH1A1 | |
| SCHEMBL12449225 | 0.77 | EPHX1 (0.47) | ROCK1TSHRPRMT6 | |
| SCHEMBL10098874 | 0.74 | ROCK1 (0.48) | MAPTROCK1LIMK2KDM4EALDH1A1 | |
| SCHEMBL9261154 | 0.74 | GRIN2D (0.47) | LOXL2TDP1HDAC3HDAC4HDAC1 | |
| SCHEMBL627450 | 0.73 | MAPT (0.44) | MAPTLOXL2KDM4EGFERALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173723-B1 | PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC (US) | 2011-08-31 | — | — | EP | disclosed |