Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 13/20 | 0.42 |
| ▸ | LMNA | P02545 | 8/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | MEN1 | O00255 | 5/20 | 0.42 |
| ▸ | TP53 | P04637 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CASP7 | P55210 | 1/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 3/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2334636 | 1.00 | MAPT (0.42) | MAPTLMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL2334639 | 1.00 | MAPT (0.42) | MAPTLMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL2333514 | 0.94 | MAPT (0.40) | MAPTLMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL2333517 | 0.94 | MAPT (0.40) | MAPTLMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL12448388 | 0.94 | MAPT (0.40) | MAPTLMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL2337190 | 0.90 | MAPT (0.44) | MAPTLMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL2338546 | 0.90 | KMT2A (0.44) | MAPTLMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL2338552 | 0.90 | KMT2A (0.44) | MAPTLMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL2337186 | 0.90 | MAPT (0.44) | MAPTLMNAKMT2AALDH1A1MEN1 | |
| SCHEMBL2334657 | 0.90 | MAPT (0.38) | MAPTLMNAKMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1465882-B1 | HETROCYCLIC MODULATORS OF NUCLEAR RECEPTORS | X CEPTOR THERAPEUTICS INC (US) | 2011-08-24 | — | — | EP | disclosed |