Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29799432 | 0.82 | EPHX2 (0.40) | GAADRD2EPHX2ESR1ESR2 | |
| SCHEMBL29799546 | 0.82 | EPHX2 (0.40) | GAADRD2EPHX2ESR1ESR2 | |
| SCHEMBL29799396 | 0.79 | KMT2A (0.41) | SMN1; SMN2GAAMAPTLMNAKDM4E | |
| SCHEMBL29799492 | 0.78 | ESR1 (0.39) | DRD2EPHX2ESR1ESR2 | |
| SCHEMBL29799563 | 0.75 | PPARG (0.41) | SMN1; SMN2DRD2MAPTLMNAKDM4E | |
| SCHEMBL20212754 | 0.69 | ESR1 (0.36) | ALDH1A1CYP2D6EPHX2ESR1ESR2 | |
| SCHEMBL6141283 | 0.69 | HDAC3 (0.54) | HRH3SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL2341136 | 0.69 | EPHX2 (0.43) | SMN1; SMN2GAADRD2MAPTLMNA | |
| SCHEMBL2346305 | 0.69 | EPHX2 (0.52) | DRD2CYP2D6EPHX2 | |
| SCHEMBL20212763 | 0.68 | CHRM1 (0.42) | CYP2D6NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257553-B1 | SUBSTITUTED SPIROCYCLIC PIPERIDINE DERIVATIVES AS HISTAMINE-3 (H3) RECEPTOR LIGANDS | CEPHALON INC (US) | 2011-08-31 | — | — | EP | disclosed |