Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 15/20 | 0.60 |
| ▸ | SYK | P43405 | 4/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2281010 | 0.89 | JAK3 (0.65) | JAK3 | |
| SCHEMBL2279333 | 0.84 | JAK3 (0.61) | JAK3SYKCYP2D6MAPK1CYP2C9 | |
| SCHEMBL2280877 | 0.84 | JAK3 (0.61) | JAK3SYKCYP2D6MAPK1CYP2C9 | |
| SCHEMBL2278825 | 0.84 | JAK3 (0.60) | JAK3SYKCYP2D6MAPK1CYP2C9 | |
| SCHEMBL2277585 | 0.84 | JAK3 (0.60) | JAK3SYKCYP2D6MAPK1CYP2C9 | |
| SCHEMBL2280567 | 0.84 | JAK3 (0.60) | JAK3SYKCYP2D6MAPK1CYP2C9 | |
| SCHEMBL1895617 | 0.84 | JAK3 (0.60) | JAK3SYKCYP2D6MAPK1CYP2C9 | |
| SCHEMBL2271733 | 0.84 | JAK3 (0.60) | JAK3SYKCYP2D6MAPK1CYP2C9 | |
| SCHEMBL2272909 | 0.84 | JAK3 (0.60) | JAK3SYKCYP2D6MAPK1CYP2C9 | |
| SCHEMBL2273798 | 0.83 | JAK3 (0.59) | JAK3SYKCYP2D6MAPK1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-B1 | PYRROLOPYRAZINE KINASE INHIBITORS | HOFFMANN LA ROCHE (CH) | 2011-08-31 | — | — | EP | disclosed |