Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 20/20 | 0.80 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.80 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13872684 | 0.92 | ELANE (0.77) | ELANECYP2C9CYP3A4 | |
| SCHEMBL8288689 | 0.90 | ELANE (0.70) | ELANECYP2C9CYP3A4 | |
| SCHEMBL13872736 | 0.90 | ELANE (0.81) | ELANECYP2C9CYP3A4 | |
| SCHEMBL13872728 | 0.89 | ELANE (0.85) | ELANECYP2C9CYP3A4 | |
| SCHEMBL13872730 | 0.89 | ELANE (0.85) | ELANECYP2C9CYP3A4 | |
| SCHEMBL1245224 | 0.89 | ELANE (1.00) | ELANECYP2C9CYP3A4 | |
| SCHEMBL3482543 | 0.89 | ELANE (1.00) | ELANECYP2C9CYP3A4 | |
| SCHEMBL5095677 | 0.88 | ELANE (0.82) | ELANECYP2C9CYP3A4 | |
| SCHEMBL8287682 | 0.86 | ELANE (0.82) | ELANECYP2C9CYP3A4 | |
| SCHEMBL3482560 | 0.86 | ELANE (0.85) | ELANECYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1730121-B1 | 1,4-DIARYL-DIHYDROPYRIMIDIN-2-ONES AND THEIR USE AS HUMAN NEUTROPHIL ELASTASE INHIBITORS | BAYER IP GMBH (DE) | 2013-08-07 | — | — | EP | disclosed |
| US-7893073-B2 | Heterocyclic derivatives | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2011-02-22 | — | — | US | disclosed |