Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 5/20 | 0.45 |
| ▸ | RPTOR | Q8N122 | 5/20 | 0.45 |
| ▸ | MLST8 | Q9BVC4 | 5/20 | 0.45 |
| ▸ | RAB9A | P51151 | 9/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.35 |
| ▸ | NPC1 | O15118 | 8/20 | 0.35 |
| ▸ | MEN1 | O00255 | 7/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2147833 | 1.00 | MTOR (0.45) | MTORRPTORMLST8RAB9AKMT2A | |
| SCHEMBL14246076 | 1.00 | MTOR (0.45) | MTORRPTORMLST8RAB9AKMT2A | |
| SCHEMBL2147336 | 0.94 | MTOR (0.47) | MTORRPTORMLST8RAB9AKMT2A | |
| SCHEMBL14245724 | 0.94 | MTOR (0.47) | MTORRPTORMLST8RAB9AKMT2A | |
| SCHEMBL14298262 | 0.94 | MTOR (0.48) | MTORRPTORMLST8RAB9AKMT2A | |
| SCHEMBL2148138 | 0.94 | MTOR (0.48) | MTORRPTORMLST8RAB9AKMT2A | |
| SCHEMBL14245423 | 0.94 | MTOR (0.48) | MTORRPTORMLST8RAB9AKMT2A | |
| SCHEMBL14298268 | 0.91 | MTOR (0.42) | MTORRPTORMLST8RAB9AKMT2A | |
| SCHEMBL2147049 | 0.91 | MTOR (0.42) | MTORRPTORMLST8RAB9AKMT2A | |
| SCHEMBL14245718 | 0.91 | MTOR (0.42) | MTORRPTORMLST8RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011090935-A1 | PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-28 | — | — | WO | disclosed |