Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 4/20 | 0.40 |
| ▸ | RPTOR | Q8N122 | 4/20 | 0.40 |
| ▸ | MLST8 | Q9BVC4 | 4/20 | 0.40 |
| ▸ | BRAF | P15056 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 4/20 | 0.31 |
| ▸ | RAB9A | P51151 | 4/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | RECQL | P46063 | 1/20 | 0.31 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14245944 | 0.91 | MTOR (0.39) | MTORRPTORMLST8BRAFMAPT | |
| SCHEMBL14245942 | 0.91 | MTOR (0.39) | MTORRPTORMLST8BRAFMAPT | |
| SCHEMBL12460267 | 0.91 | MTOR (0.39) | MTORRPTORMLST8BRAFMAPT | |
| SCHEMBL14298177 | 0.91 | MTOR (0.39) | MTORRPTORMLST8BRAFMAPT | |
| SCHEMBL12460278 | 0.89 | MTOR (0.51) | MTORRPTORMLST8NPC1RAB9A | |
| SCHEMBL12460874 | 0.89 | MTOR (0.51) | MTORRPTORMLST8NPC1RAB9A | |
| SCHEMBL14245547 | 0.89 | MTOR (0.51) | MTORRPTORMLST8NPC1RAB9A | |
| SCHEMBL2147372 | 0.89 | MTOR (0.51) | MTORRPTORMLST8NPC1RAB9A | |
| SCHEMBL2147228 | 0.85 | MTOR (0.53) | MTORRPTORMLST8BRAF | |
| SCHEMBL14245610 | 0.85 | MTOR (0.53) | MTORRPTORMLST8BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011090935-A1 | PYRAZOLO[1,5-a]PYRIMIDINE COMPOUNDS AS mTOR INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2011-07-28 | — | — | WO | disclosed |