Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 7/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | APP | P05067 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1495290 | 0.89 | GRM2 (0.53) | GRM2SMN1; SMN2NPSR1KMT2APOLB | |
| SCHEMBL12831411 | 0.89 | GRM2 (0.53) | GRM2SMN1; SMN2NPSR1KMT2APOLB | |
| SCHEMBL1245401 | 0.88 | GRM2 (0.53) | GRM2SMN1; SMN2NPSR1KMT2APOLB | |
| SCHEMBL1495201 | 0.88 | GRM2 (0.55) | GRM2SMN1; SMN2NPSR1KMT2APOLB | |
| SCHEMBL1246003 | 0.88 | GRM2 (0.53) | GRM2SMN1; SMN2NPSR1KMT2APOLB | |
| SCHEMBL1246518 | 0.87 | GRM2 (0.52) | GRM2SMN1; SMN2NPSR1KMT2APOLB | |
| SCHEMBL1495099 | 0.85 | GRM2 (0.54) | GRM2SMN1; SMN2NPSR1KMT2APOLB | |
| SCHEMBL1245490 | 0.85 | GRM2 (0.56) | GRM2SMN1; SMN2NPSR1KMT2APOLB | |
| SCHEMBL1495105 | 0.84 | GRM2 (0.53) | GRM2SMN1; SMN2NPSR1KMT2APOLB | |
| SCHEMBL1495157 | 0.84 | GRM2 (0.56) | GRM2SMN1; SMN2NPSR1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110065669-A1 | OXAZOLOBENZIMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-17 | — | — | US | claimed |
| EP-2279532-A2 | OXAZOLOBENZIMIDAZOLE DERIVATIVES | Merck Sharp & Dohme Corp. (US) | 2011-02-02 | — | — | EP | claimed |
| WO-2009140166-A2 | OXAZOLOBENZIMIDAZOLE DERIVATIVES | MERCK & CO., INC. (US) | 2009-11-19 | — | — | WO | claimed |
| US-20110065669-A1 | OXAZOLOBENZIMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-17 | — | — | US | disclosed |
| US-20110065669-A1 | OXAZOLOBENZIMIDAZOLE DERIVATIVES | MERCK SHARP & DOHME CORP. (US) | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065669-A1 | OXAZOLOBENZIMIDAZOLE DERIVATIVES | GRM2, GRM1, GRM3 | GRM2 1/4885SMN1; SMN2 1055/4885NPSR1 306/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.