Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.68 |
| ▸ | RAB9A | P51151 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | NAMPT | P43490 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16431496 | 0.89 | BCL3 (0.62) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL29849764 | 0.89 | BCL3 (0.62) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL3861140 | 0.88 | TSHR (0.60) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL15038304 | 0.87 | NPC1 (0.70) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL31419615 | 0.85 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL5636190 | 0.85 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL13753123 | 0.84 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL5636257 | 0.84 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL31188513 | 0.82 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA | |
| SCHEMBL19606710 | 0.82 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8697691-B2 | Alkyl 3-((2-amidoethyl)amino)-8-azabicyclo[3.2.1]octane-8-carboxylate analogs as selective M1 agonists and methods of making and using same | VANDERBILT UNIVERSITY (US) | 2014-04-15 | — | — | US | disclosed |
| CN-102225927-A | Amide fragment-containing (Z)-type nitenpyram compound and preparation method and application thereof | UNIV SHANGHAI | 2011-10-26 | — | — | CN | disclosed |
| WO-2011087812-A1 | ALKYL 3-((2-AMIDOETHYL)AMINO)-8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE ANALOGS AS SELECTIVE M1 AGONISTS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY (US) | 2011-07-21 | — | — | WO | disclosed |
| US-20110172227-A1 | ALKYL 3-((2-AMIDOETHYL)AMINO)-8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE ANALOGS AS SELECTIVE M1 AGONISTS AND METHODS OF MAKING AND USING SAME | VANDERBILT UNIVERSITY | 2011-07-14 | — | — | US | disclosed |
| CN-102067838-A | Amide fragment-containing (Z) type nitenpyram analogue pesticide and preparation method thereof | UNIV SHANGHAI | 2011-05-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110172227-A1 | ALKYL 3-((2-AMIDOETHYL)AMINO)-8-AZABICYCLO[3.2.1]OCTANE-8-CARBOXYLATE ANALOGS AS SELECTIVE M1 AGONISTS AND METHODS OF MAKING AND USING SAME | CHRM1, CHRM2, CHRM5 | NPC1 861/4885RAB9A 1774/4885SMN1; SMN2 1428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.