Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 3/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | AXL | P30530 | 2/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 6/20 | 0.36 |
| ▸ | TGFBR2 | P37173 | 4/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5134352 | 0.79 | ADORA2A (0.44) | ADORA2AADORA1PRKCIDYRK1AAXL | |
| Ammonia Solution, Strong SCHEMBL18806383 | 0.78 | ADORA2A (0.43) | ADORA2AADORA1PRKCIDYRK1AAXL | |
| SCHEMBL2147990 | 0.76 | PRKCI (0.41) | ADORA2AADORA1PRKCIDYRK1AAXL | |
| SCHEMBL1689372 | 0.76 | DYRK1A (0.46) | ADORA2AADORA1PRKCIDYRK1AAXL | |
| SCHEMBL20748444 | 0.76 | ADORA2A (0.42) | ADORA2AADORA1PRKCIDYRK1AAXL | |
| SCHEMBL9912500 | 0.76 | PIK3CA (0.50) | ADORA2AADORA1PRKCIDYRK1AAXL | |
| SCHEMBL12574854 | 0.76 | PRKCI (0.46) | ADORA2AADORA1PRKCIDYRK1AAXL | |
| SCHEMBL12395339 | 0.76 | JAK3 (0.36) | ADORA2AADORA1PRKCIDYRK1AAXL | |
| SCHEMBL23170164 | 0.74 | ADORA2A (0.41) | ADORA2AADORA1PRKCIDYRK1AAXL | |
| SCHEMBL14029857 | 0.73 | ADORA2A (0.43) | ADORA2AADORA1PRKCIDYRK1AAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110165183-A1 | PIPERIDINE DERIVATIVES AS JAK3 INHIBITORS | BIOCRYST PHARMACEUTICALS, INC. (US) | 2011-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110165183-A1 | PIPERIDINE DERIVATIVES AS JAK3 INHIBITORS | JAK3, JAK2, JAK1 | ADORA2A 2515/4885ADORA1 2238/4885PRKCI 419/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.