Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 1.00 |
| ▸ | MTOR | P42345 | 6/20 | 0.70 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.69 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.69 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.69 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.69 |
| ▸ | PRKACA | P17612 | 1/20 | 0.69 |
| ▸ | PRKACG | P22612 | 1/20 | 0.69 |
| ▸ | PRKACB | P22694 | 1/20 | 0.69 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.69 |
| ▸ | CDK2 | P24941 | 1/20 | 0.69 |
| ▸ | KDR | P35968 | 1/20 | 0.69 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28799921 | 0.87 | PIK3CA (0.77) | PIK3CAMTORPIK3CGPIK3CBPIK3C2B | |
| SCHEMBL1301231 | 0.85 | PIK3CA (0.76) | PIK3CAMTORPIK3CGPIK3CBPIK3C2B | |
| SCHEMBL960919 | 0.84 | PIK3CA (0.87) | PIK3CAMTORPIK3CGPIK3CBPIK3C2B | |
| SCHEMBL964649 | 0.83 | PIK3CA (0.86) | PIK3CAMTORPIK3CGPIK3CBPIK3C2B | |
| SCHEMBL958760 | 0.82 | PIK3CA (0.86) | PIK3CAMTORPIK3CGPIK3CBPIK3C2B | |
| SCHEMBL960078 | 0.82 | PIK3CA (1.00) | PIK3CAMTORPIK3CGPIK3CBPIK3C2B | |
| SCHEMBL29439930 | 0.82 | PIK3CA (1.00) | PIK3CAMTORPIK3CGPIK3CBPIK3C2B | |
| SCHEMBL258501 | 0.82 | PIK3CA (1.00) | PIK3CAMTORPIK3CGPIK3CBPIK3C2B | |
| SCHEMBL29395747 | 0.82 | PIK3CA (1.00) | PIK3CAMTORPIK3CGPIK3CBPIK3C2B | |
| SCHEMBL959755 | 0.81 | PIK3CA (0.81) | PIK3CAMTORPIK3CGPIK3CBPIK3C2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011082285-A1 | LIGAND-DIRECTED COVALENT MODIFICATION OF PROTEIN | AVILA THERAPEUTICS, INC. (US) | 2011-07-07 | — | — | WO | disclosed |