Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MIF | P14174 | 8/20 | 0.53 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.53 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.53 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.53 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.53 |
| ▸ | NAAA | Q02083 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 4/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.42 |
| ▸ | HTR2A | P28223 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8987415 | 0.80 | MIF (0.46) | MIFTRPA1CYP2E1CYP2A6HIF1A | |
| SCHEMBL1247842 | 0.79 | HRH1 (0.45) | ALDH1A1CYP3A4HRH1HTR2A | |
| SCHEMBL1247579 | 0.78 | MIF (0.50) | MIFTRPA1CYP2E1CYP2A6HIF1A | |
| SCHEMBL14216820 | 0.76 | HRH1 (0.50) | ALDH1A1CYP3A4HRH1HTR2A | |
| SCHEMBL8101646 | 0.74 | MIF (0.57) | MIFTRPA1CYP2E1CYP2A6HIF1A | |
| Hydrochloric Acid SCHEMBL28151898 | 0.74 | HRH1 (0.48) | ALDH1A1CYP3A4HRH1HTR2A | |
| SCHEMBL8763999 | 0.72 | MIF (0.48) | MIFTRPA1CYP2E1CYP2A6HIF1A | |
| SCHEMBL8101546 | 0.72 | MIF (0.54) | MIFTRPA1CYP2E1CYP2A6HIF1A | |
| SCHEMBL9957097 | 0.72 | MIF (0.55) | MIFTRPA1CYP2E1CYP2A6HIF1A | |
| SCHEMBL29028764 | 0.71 | HRH1 (0.50) | ALDH1A1CYP3A4HRH1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9708255-B2 | (bis)urea and (bis)thiourea compounds as epigenic modulators of lysine-specific demethylase 1 and methods of treating disorders | Casero, Robert A. (US) | 2017-07-18 | — | — | US | disclosed |
| US-20120322877-A1 | (BIS)UREA AND (BIS)THIOREA COMPOUNDS AS EIPGENIC MODULATORS OF LYSINE-SPECIFIC DEMETHYLASE 1 AND METHODS OF TREATING DISORDERS | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2012-12-20 | — | — | US | disclosed |
| EP-2467359-A2 | (BIS) UREA AND (BIS) THIOUREA COMPOUNDS AS EPIGENIC MODULATORS OF LYSINE-SPECIFIC DEMETHYLASE 1 AND METHODS OF TREATING DISORDERS | The Johns Hopkins University (US) | 2012-06-27 | — | — | EP | disclosed |
| WO-2011022489-A2 | (BIS) UREA AND (BIS) THIOUREA COMPOUNDS AS EPIGENIC MODULATORS OF LYSINE-SPECIFIC DEMETHYLASE 1 AND METHODS OF TREATING DISORDERS | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-02-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120322877-A1 | (BIS)UREA AND (BIS)THIOREA COMPOUNDS AS EIPGENIC MODULATORS OF LYSINE-SPECIFIC DEMETHYLASE 1 AND METHODS OF TREATING DISORDERS | KDM4A, KDM1A, EHMT1 | MIF 4685/4885TRPA1 3987/4885CYP2E1 418/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.