Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 9/20 | 0.55 |
| ▸ | SCN5A | Q14524 | 6/20 | 0.55 |
| ▸ | LPAR1 | Q92633 | 2/20 | 0.46 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.46 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1246478 | 0.94 | SCN9A (0.52) | SCN9ASCN5ALPAR1LPAR2LPAR3 | |
| SCHEMBL1245362 | 0.94 | SCN9A (0.57) | SCN9ASCN5ALPAR1LPAR2LPAR3 | |
| SCHEMBL1246308 | 0.93 | SCN9A (0.55) | SCN9ASCN5ALPAR1LPAR2LPAR3 | |
| SCHEMBL1245178 | 0.91 | SCN9A (0.55) | SCN9ASCN5ALPAR1LPAR2LPAR3 | |
| SCHEMBL1246198 | 0.89 | SCN9A (0.53) | SCN9ASCN5APTGS2NTRK1GAA | |
| SCHEMBL1246481 | 0.89 | SCN9A (0.54) | SCN9ASCN5ALPAR1LPAR2LPAR3 | |
| SCHEMBL1247109 | 0.89 | SCN9A (0.51) | SCN9ASCN5ALPAR1LPAR2LPAR3 | |
| SCHEMBL1246466 | 0.89 | SCN9A (0.50) | SCN9ASCN5ALPAR1LPAR2LPAR3 | |
| SCHEMBL1246348 | 0.88 | SCN9A (0.54) | SCN9ASCN5ALPAR1LPAR2LPAR3 | |
| SCHEMBL1246304 | 0.88 | SCN9A (0.50) | SCN9ASCN5APTGS2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2462128-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-06-13 | — | — | EP | claimed |
| WO-2011017350-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-02-10 | — | — | WO | claimed |