Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 9/20 | 0.56 |
| ▸ | BCR | P11274 | 8/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.51 |
| ▸ | BRAF | P15056 | 3/20 | 0.50 |
| ▸ | RAF1 | P04049 | 2/20 | 0.50 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HCK | P08631 | 2/20 | 0.48 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.48 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.48 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | LCK | P06239 | 1/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.48 |
| ▸ | YES1 | P07947 | 1/20 | 0.48 |
| ▸ | LYN | P07948 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12465115 | 0.93 | ABL1 (0.58) | ABL1BCRCSF1RBRAFRAF1 | |
| SCHEMBL12465166 | 0.88 | ABL1 (0.53) | ABL1BCRCSF1RBRAFRAF1 | |
| SCHEMBL12464972 | 0.88 | ABL1 (0.52) | ABL1BCRCSF1RBRAFRAF1 | |
| SCHEMBL13960023 | 0.87 | CSF1R (0.52) | ABL1BCRCSF1RBRAFRAF1 | |
| SCHEMBL12398126 | 0.85 | ABL1 (0.69) | ABL1BCRCSF1RBRAFRAF1 | |
| SCHEMBL12398112 | 0.84 | ABL1 (0.68) | ABL1BCRCSF1RBRAFRAF1 | |
| SCHEMBL12398255 | 0.83 | ABL1 (0.67) | ABL1BCRCSF1RBRAFRAF1 | |
| SCHEMBL12398258 | 0.82 | ABL1 (0.66) | ABL1BCRCSF1RBRAFRAF1 | |
| SCHEMBL12465149 | 0.82 | ABL1 (0.59) | ABL1BCRCSF1RBRAFRAF1 | |
| SCHEMBL12398117 | 0.81 | ABL1 (0.70) | ABL1BCRCSF1RBRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2173734-B1 | CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INT (DE) | 2016-03-23 | — | — | EP | disclosed |
| US-8889665-B2 | Chemical compounds | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-11-18 | — | — | US | disclosed |
| US-20110183952-A1 | NEW CHEMICAL COMPOUNDS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2011-07-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110183952-A1 | NEW CHEMICAL COMPOUNDS | MKI67, CCNA1, CCNT1 | ABL1 136/4885BCR 922/4885CSF1R 594/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.