Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 8/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1495289 | 0.85 | GRM2 (0.53) | POLBKMT2AL3MBTL1GRM2KDM4E | |
| SCHEMBL1512226 | 0.83 | GRM2 (0.47) | POLBKMT2AL3MBTL1GRM2KDM4E | |
| SCHEMBL1495060 | 0.83 | GRM2 (0.45) | POLBKMT2AL3MBTL1GRM2KDM4E | |
| SCHEMBL1245956 | 0.82 | KMT2A (0.44) | POLBKMT2AL3MBTL1GRM2KDM4E | |
| SCHEMBL1495305 | 0.82 | GRM2 (0.50) | POLBKMT2AL3MBTL1GRM2KDM4E | |
| SCHEMBL1246280 | 0.81 | GRM2 (0.47) | POLBKMT2AL3MBTL1GRM2KDM4E | |
| SCHEMBL1245490 | 0.81 | GRM2 (0.56) | POLBKMT2AL3MBTL1GRM2KDM4E | |
| SCHEMBL1495124 | 0.79 | GRM2 (0.53) | POLBKMT2AL3MBTL1GRM2KDM4E | |
| SCHEMBL1246625 | 0.78 | GRM2 (0.41) | POLBKMT2AL3MBTL1GRM2KDM4E | |
| SCHEMBL1495292 | 0.78 | GRM2 (0.45) | POLBKMT2AL3MBTL1GRM2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2279532-A2 | OXAZOLOBENZIMIDAZOLE DERIVATIVES | Merck Sharp & Dohme Corp. (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009140166-A2 | OXAZOLOBENZIMIDAZOLE DERIVATIVES | MERCK & CO., INC. (US) | 2009-11-19 | — | — | WO | disclosed |