SCHEMBL12465624

SCHEMBL12465624

COc1cccc(-c2cc(F)ccc2[C@@H]2Cc3nc(N)nc(C)c3C(=O)N2)n1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 20/20 1.00
HSP90AB1 P08238 11/20 1.00
TRAP1 Q12931 1/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1351190 1.00 HSP90AA1 (1.00) HSP90AA1HSP90AB1TRAP1
SCHEMBL1351184 1.00 HSP90AA1 (1.00) HSP90AA1HSP90AB1TRAP1
SCHEMBL29352985 1.00 HSP90AA1 (1.00) HSP90AA1HSP90AB1TRAP1
SCHEMBL1985674 0.95 HSP90AA1 (1.00) HSP90AA1HSP90AB1TRAP1
SCHEMBL1985679 0.95 HSP90AA1 (1.00) HSP90AA1HSP90AB1TRAP1
SCHEMBL1986232 0.92 HSP90AA1 (1.00) HSP90AA1HSP90AB1TRAP1
SCHEMBL1988210 0.92 HSP90AA1 (1.00) HSP90AA1HSP90AB1TRAP1
SCHEMBL1985089 0.91 HSP90AA1 (1.00) HSP90AA1HSP90AB1TRAP1
SCHEMBL1985085 0.91 HSP90AA1 (1.00) HSP90AA1HSP90AB1TRAP1
SCHEMBL1987780 0.91 HSP90AA1 (1.00) HSP90AA1HSP90AB1TRAP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2252595-B1 OXIM DERIVATIVES AS HSP90 INHIBITORS TAKEDA PHARMACEUTICAL (JP) 2014-03-26 EP claimed
WO-2012104823-A2 PYRIDOPYRIMIDINONE COMPOUNDS IN THE TREATMENT OF NEURODEGENERATIVE DISEASES NOVARTIS AG (CH) 2012-08-09 WO disclosed