Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNT1 | O60563 | 17/20 | 0.56 |
| ▸ | CCNK | O75909 | 3/20 | 0.50 |
| ▸ | CDK9 | P50750 | 3/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1225400 | 0.93 | CCNT1 (0.58) | CCNT1CCNKCDK9 | |
| SCHEMBL1192432 | 0.88 | CCNT1 (0.73) | CCNT1CCNKCDK9 | |
| SCHEMBL1225395 | 0.85 | CCNT1 (0.64) | CCNT1CCNKCDK9 | |
| SCHEMBL12465693 | 0.85 | CCNT1 (0.71) | CCNT1CCNKCDK9 | |
| SCHEMBL1192618 | 0.84 | CCNT1 (0.78) | CCNT1CCNKCDK9 | |
| SCHEMBL1192616 | 0.84 | CCNT1 (0.78) | CCNT1CCNKCDK9 | |
| SCHEMBL1439786 | 0.82 | CCNT1 (0.54) | CCNT1CCNKCDK9 | |
| SCHEMBL1191780 | 0.80 | CCNK (0.59) | CCNT1CCNKCDK9 | |
| SCHEMBL12466095 | 0.79 | CCNT1 (0.59) | CCNT1CCNKCDK9 | |
| SCHEMBL12820006 | 0.79 | CCNT1 (0.54) | CCNT1CCNKCDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2668162-A1 | SUBSTITUTED BI-HETEROARYL COMPOUNDS AS CDK9 INHIBITORS AND THEIR USES | Novartis AG (CH) | 2013-12-04 | — | — | EP | disclosed |
| WO-2012101065-A2 | PYRIMIDINE BIARYL AMINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2012-08-02 | — | — | WO | disclosed |
| WO-2012101066-A1 | PYRIDINE BIARYL AMINE COMPOUNDS AND THEIR USES | NOVARTIS AG (CH) | 2012-08-02 | — | — | WO | disclosed |
| WO-2012101062-A1 | SUBSTITUTED BI-HETEROARYL COMPOUNDS AS CDK9 INHIBITORS AND THEIR USES | NOVARTIS AG (CH) | 2012-08-02 | — | — | WO | disclosed |