Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | GLA | P06280 | 1/20 | 0.55 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.55 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.55 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | CCR3 | P51677 | 3/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | CCR5 | P51681 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12466321 | 0.87 | MEN1 (0.67) | MEN1KMT2ATPSAB1TPSD1TPSG1 | |
| SCHEMBL12685846 | 0.86 | MEN1 (0.85) | MEN1KMT2ATPSAB1TPSD1TPSG1 | |
| SCHEMBL12466499 | 0.85 | KMT2A (0.67) | MEN1KMT2ATPSAB1TPSD1TPSG1 | |
| Hydrochloric Acid SCHEMBL12466326 | 0.85 | MEN1 (0.83) | MEN1KMT2ATPSAB1TPSD1TPSG1 | |
| Hydrochloric Acid SCHEMBL12466676 | 0.84 | MEN1 (0.65) | MEN1KMT2ASMN1; SMN2TPSAB1TPSD1 | |
| SCHEMBL12466643 | 0.84 | MEN1 (0.65) | MEN1KMT2ATPSAB1TPSD1TPSG1 | |
| SCHEMBL13873636 | 0.81 | MEN1 (0.61) | MEN1KMT2ASMN1; SMN2GLAPKM | |
| SCHEMBL4775057 | 0.79 | SMN1; SMN2 (0.63) | MEN1KMT2ASMN1; SMN2CCR3CCR5 | |
| SCHEMBL12466523 | 0.79 | MEN1 (0.65) | MEN1KMT2ASMN1; SMN2TPSAB1TPSD1 | |
| SCHEMBL24449599 | 0.78 | GLA (0.53) | MEN1KMT2ASMN1; SMN2GLAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2668157-A1 | PROTEASE ACTIVATED RECEPTOR 2 (PAR2) ANTAGONISTS | Proximagen Limited (GB) | 2013-12-04 | — | — | EP | claimed |
| WO-2012101453-A1 | PROTEASE ACTIVATED RECEPTOR 2 (PAR2) ANTAGONISTS | PROXIMAGEN LTD. (GB) | 2012-08-02 | — | — | WO | claimed |
| US-20130324556-A1 | Protease Activated Receptor 2 (PAR2) Antagonists | PROXIMAGEN LTD. (GB) | 2013-12-05 | — | — | US | disclosed |
| EP-2668157-A1 | PROTEASE ACTIVATED RECEPTOR 2 (PAR2) ANTAGONISTS | Proximagen Limited (GB) | 2013-12-04 | — | — | EP | disclosed |
| WO-2012101453-A1 | PROTEASE ACTIVATED RECEPTOR 2 (PAR2) ANTAGONISTS | PROXIMAGEN LTD. (GB) | 2012-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130324556-A1 | Protease Activated Receptor 2 (PAR2) Antagonists | F2RL1, F2R, F2RL3 | MEN1 1376/4885KMT2A 2337/4885SMN1; SMN2 3325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.