Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 9/20 | 0.55 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.50 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | QPCT | Q16769 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.44 |
| ▸ | CYP2J2 | P51589 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13873498 | 0.81 | EPHX2 (0.64) | EPHX2CHRNA7ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL4114824 | 0.80 | EPHX2 (0.70) | EPHX2CHRNA7ALDH1A1TSHRCYP2C9 | |
| SCHEMBL13873825 | 0.79 | EPHX2 (0.55) | EPHX2CHRNA7ALDH1A1TSHRKIT | |
| SCHEMBL4101221 | 0.79 | EPHX2 (0.61) | EPHX2CHRNA7ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL4105262 | 0.79 | CHRNA7 (0.66) | EPHX2CHRNA7ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL12466289 | 0.79 | EPHX2 (0.61) | EPHX2CHRNA7ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL12466669 | 0.78 | MEN1 (0.65) | EPHX2 | |
| SCHEMBL4106438 | 0.77 | EPHX2 (0.60) | EPHX2CHRNA7ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL7096653 | 0.77 | EPHX2 (0.59) | EPHX2CHRNA7ALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL13890321 | 0.77 | EPHX2 (0.59) | EPHX2CHRNA7ALDH1A1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2668157-A1 | PROTEASE ACTIVATED RECEPTOR 2 (PAR2) ANTAGONISTS | Proximagen Limited (GB) | 2013-12-04 | — | — | EP | disclosed |
| WO-2012101453-A1 | PROTEASE ACTIVATED RECEPTOR 2 (PAR2) ANTAGONISTS | PROXIMAGEN LTD. (GB) | 2012-08-02 | — | — | WO | disclosed |