Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 5/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 2/20 | 0.33 |
| ▸ | MMP3 | P08254 | 1/20 | 0.33 |
| ▸ | BMP1 | P13497 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12468320 | 0.98 | HPGD (0.44) | KMT2AHPGDEPHX1NPC1RAB9A | |
| SCHEMBL12468248 | 0.98 | HPGD (0.44) | KMT2AHPGDEPHX1NPC1RAB9A | |
| SCHEMBL12466930 | 0.98 | HPGD (0.44) | KMT2AHPGDEPHX1NPC1RAB9A | |
| SCHEMBL12467414 | 0.98 | HPGD (0.44) | KMT2AHPGDEPHX1NPC1RAB9A | |
| SCHEMBL12468388 | 0.88 | ACACB (0.32) | — | |
| SCHEMBL12467285 | 0.85 | HPGD (0.47) | KMT2AHPGDNPC1RAB9AGAA | |
| SCHEMBL12487137 | 0.84 | — | — | |
| SCHEMBL12468385 | 0.84 | HPGD (0.40) | KMT2AHPGDEPHX1NPC1RAB9A | |
| SCHEMBL14943373 | 0.84 | KMT2A (0.43) | KMT2AHPGDEPHX1NPC1RAB9A | |
| SCHEMBL15219810 | 0.83 | HPGD (0.46) | KMT2AHPGDEPHX1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7964624-B1 | Inhibitors of serine proteases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-06-21 | — | — | US | disclosed |