Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 2/20 | 0.43 |
| ▸ | IGF1R | P08069 | 2/20 | 0.43 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.41 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17766549 | 0.77 | MAPK1 (0.47) | MAPK3MAPK1KMT2AHDAC6KAT2B | |
| SCHEMBL31391653 | 0.75 | GRIK1 (0.49) | GAAMAPK3MAPK1KMT2AKAT2B | |
| SCHEMBL1220618 | 0.74 | KDM4E (0.51) | MAPK3MAPK1KAT2BBAZ2BCREBBP | |
| SCHEMBL17646442 | 0.73 | CHRM3 (0.45) | — | |
| SCHEMBL10371031 | 0.72 | CDK1 (0.43) | POLBKAT2B | |
| SCHEMBL3642902 | 0.72 | GAA (0.50) | GAAPOLB | |
| SCHEMBL22605677 | 0.71 | JAK2 (0.50) | HDAC8HDAC6 | |
| SCHEMBL12415575 | 0.70 | KDM4E (0.55) | GAAPOLBKMT2A | |
| SCHEMBL17766571 | 0.70 | CXCR2 (0.48) | MAPK3MAPK1HDAC6KAT2BBAZ2B | |
| SCHEMBL17766548 | 0.69 | MAPK3 (0.41) | MAPK3MAPK1KMT2AHDAC6KAT2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3233840-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | Eudendron S.r.l. (IT) | 2017-10-25 | — | — | EP | claimed |
| WO-2016096709-A1 | HETEROCYCLIC DERIVATIVES MODULATING ACTIVITY OF CERTAIN PROTEIN KINASES | EUDENDRON S.R.L. (IT) | 2016-06-23 | — | — | WO | claimed |
| EP-3227686-A1 | MULTIPLEXED IMMUNOHISTOCHEMISTRY ASSAYS FOR DIAGNOSIS AND TREATMENT OF CANCER | Ignyta, Inc. (US) | 2017-10-11 | — | — | EP | disclosed |
| EP-3227276-A1 | COMBINATIONS FOR THE TREATMENT OF NEUROBLASTOMA | Ignyta, Inc. (US) | 2017-10-11 | — | — | EP | disclosed |
| WO-2016089760-A1 | COMBINATIONS FOR THE TREATMENT OF NEUROBLASTOMA | IGNYTA, INC. (US) | 2016-06-09 | — | — | WO | disclosed |
| WO-2016089853-A1 | MULTIPLEXED IMMUNOHISTOCHEMISTRY ASSAYS FOR DIAGNOSIS AND TREATMENT OF CANCER | IGNYTA, INC. (US) | 2016-06-09 | — | — | WO | disclosed |
| EP-2668184-A1 | DERIVATIVES OF AZAINDAZOLE OR DIAZAINDAZOLE TYPE AS MEDICAMENT | Pierre Fabre Medicament (FR) | 2013-12-04 | — | — | EP | disclosed |
| WO-2012101239-A1 | DERIVATIVES OF AZAINDAZOLE OR DIAZAINDAZOLE TYPE AS MEDICAMENT | PIERRE FABRE MEDICAMENT (FR) | 2012-08-02 | — | — | WO | disclosed |