Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | EIF4E | P06730 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16059522 | 1.00 | KDM4E (0.39) | KDM4EALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL16061091 | 0.83 | MAPT (0.41) | KDM4EALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL468181 | 0.79 | KDM4E (0.37) | KDM4EALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL468068 | 0.76 | KDM4E (0.43) | KDM4EALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL3926184 | 0.73 | KDM4E (0.41) | KDM4EALDH1A1SMN1; SMN2NPC1MAPT | |
| SCHEMBL683502 | 0.72 | MAPT (0.41) | KDM4ENPC1MAPTLMNAMEN1 | |
| SCHEMBL501297 | 0.72 | MAPT (0.41) | KDM4ENPC1MAPTLMNAMEN1 | |
| SCHEMBL17083263 | 0.72 | MAPT (0.41) | KDM4ENPC1MAPTLMNAMEN1 | |
| SCHEMBL23303496 | 0.72 | PTPRB (0.40) | KDM4EALDH1A1NPC1MAPTLMNA | |
| SCHEMBL23303492 | 0.72 | PTPRB (0.40) | KDM4EALDH1A1NPC1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2624916-A2 | COMPOSITIONS AND METHODS FOR TREATING OCULAR EDEMA, NEOVASCULARIZATION AND RELATED DISEASES | Aerpio Therapeutics Inc. (US) | 2013-08-14 | — | — | EP | disclosed |
| WO-2012047966-A2 | COMPOSITIONS AND METHODS FOR TREATING OCULAR EDEMA, NEOVASCULARIZATION AND RELATED DISEASES | AKEBIA THERAPEUTICS INC. (US) | 2012-04-12 | — | — | WO | disclosed |