Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | APAF1 | O14727 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.50 |
| ▸ | FDPS | P14324 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PON1 | P27169 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL372497 | 0.98 | SMN1; SMN2 (0.52) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B | |
| Bromide SCHEMBL2229889 | 0.96 | SMN1; SMN2 (0.55) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B | |
| Hydrochloric Acid SCHEMBL6114821 | 0.96 | SMN1; SMN2 (0.50) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B | |
| SCHEMBL26695497 | 0.89 | SMN1; SMN2 (0.51) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B | |
| SCHEMBL2527601 | 0.86 | SMN1; SMN2 (0.58) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B | |
| SCHEMBL3118979 | 0.86 | SMN1; SMN2 (0.42) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B | |
| Hydrochloric Acid SCHEMBL6115353 | 0.85 | SMN1; SMN2 (0.56) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B | |
| SCHEMBL2525893 | 0.85 | SMN1; SMN2 (0.61) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B | |
| SCHEMBL16674008 | 0.83 | SMN1; SMN2 (0.53) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B | |
| SCHEMBL17706398 | 0.83 | SMN1; SMN2 (0.46) | SMN1; SMN2MEN1APAF1NPC1PLA2G1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102725905-B | Electrolyte for dye-sensitized solar cell and dye-sensitized solar cell using the same | CARLIT HOLDINGS CO.,LTD. (JP) | 2015-11-25 | — | — | CN | disclosed |
| EP-2621939-B1 | FUNCTIONALIZED FLUOROALKYL FLUOROPHOSPHATE SALTS | MERCK PATENT GMBH (DE) | 2015-06-10 | — | — | EP | disclosed |
| US-8846922-B2 | Functionalized fluoroalkyl fluorophosphate salts | MERCK PATENT GMBH (DE) | 2014-09-30 | — | — | US | disclosed |
| EP-2621939-A1 | FUNCTIONALIZED FLUOROALKYL FLUOROPHOSPHATE SALTS | Merck Patent GmbH (DE) | 2013-08-07 | — | — | EP | disclosed |
| US-20130197228-A1 | FUNCTIONALIZED FLUOROALKYL FLUOROPHOSPHATE SALTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 2013-08-01 | — | — | US | disclosed |
| WO-2012048772-A1 | FUNCTIONALIZED FLUOROALKYL FLUOROPHOSPHATE SALTS | MERCK PATENT GMBH (DE) | 2012-04-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130197228-A1 | FUNCTIONALIZED FLUOROALKYL FLUOROPHOSPHATE SALTS | INPPL1, INPP5D, PLCB3 | SMN1; SMN2 4544/4885MEN1 3854/4885APAF1 1164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.