Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.60 |
| ▸ | CTSD | P07339 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12471133 | 1.00 | BACE1 (1.00) | BACE1KCNH2CTSD | |
| SCHEMBL12471545 | 1.00 | BACE1 (1.00) | BACE1KCNH2CTSD | |
| SCHEMBL15418740 | 0.87 | BACE1 (0.81) | BACE1KCNH2CTSD | |
| SCHEMBL2371838 | 0.87 | BACE1 (0.81) | BACE1KCNH2CTSD | |
| SCHEMBL2521153 | 0.87 | BACE1 (0.81) | BACE1KCNH2CTSD | |
| SCHEMBL12471232 | 0.84 | BACE1 (0.73) | BACE1KCNH2CTSD | |
| SCHEMBL2516634 | 0.84 | BACE1 (0.79) | BACE1KCNH2CTSD | |
| SCHEMBL15510062 | 0.82 | BACE1 (1.00) | BACE1KCNH2CTSD | |
| SCHEMBL2521048 | 0.82 | BACE1 (0.69) | BACE1KCNH2CTSD | |
| SCHEMBL2521049 | 0.82 | BACE1 (0.69) | BACE1KCNH2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9346827-B2 | 5-amino-oxazepine and 5-amino-thiazepane compounds as beta secretase antagonists and methods of use | AMGEN INC. (US) | 2016-05-24 | — | — | US | claimed |
| US-20140031340-A1 | 5-Amino-Oxazepine and 5-Amino-Thiazepane Compounds as Beta Secretase Antagonists and Methods of Use | AMGEN INC. (US) | 2014-01-30 | — | — | US | claimed |
| EP-2673279-A1 | 5-AMINO-OXAZEPINE AND 5-AMINO-THIAZEPANE COMPOUNDS AS BETA-SECRETASE ANTAGONISTS AND METHODS OF USE | Amgen Inc. (US) | 2013-12-18 | — | — | EP | claimed |
| WO-2012109165-A1 | 5-AMINO-OXAZEPINE AND 5-AMINO-THIAZEPANE COMPOUNDS AS BETA-SECRETASE ANTAGONISTS AND METHODS OF USE | AMGEN INC. (US) | 2012-08-16 | — | — | WO | claimed |
| US-9346827-B2 | 5-amino-oxazepine and 5-amino-thiazepane compounds as beta secretase antagonists and methods of use | AMGEN INC. (US) | 2016-05-24 | — | — | US | disclosed |
| US-9346827-B2 | 5-amino-oxazepine and 5-amino-thiazepane compounds as beta secretase antagonists and methods of use | AMGEN INC. (US) | 2016-05-24 | — | — | US | disclosed |
| US-20140031340-A1 | 5-Amino-Oxazepine and 5-Amino-Thiazepane Compounds as Beta Secretase Antagonists and Methods of Use | AMGEN INC. (US) | 2014-01-30 | — | — | US | disclosed |
| US-20140031340-A1 | 5-Amino-Oxazepine and 5-Amino-Thiazepane Compounds as Beta Secretase Antagonists and Methods of Use | AMGEN INC. (US) | 2014-01-30 | — | — | US | disclosed |
| EP-2673279-A1 | 5-AMINO-OXAZEPINE AND 5-AMINO-THIAZEPANE COMPOUNDS AS BETA-SECRETASE ANTAGONISTS AND METHODS OF USE | Amgen Inc. (US) | 2013-12-18 | — | — | EP | disclosed |
| WO-2012109165-A1 | 5-AMINO-OXAZEPINE AND 5-AMINO-THIAZEPANE COMPOUNDS AS BETA-SECRETASE ANTAGONISTS AND METHODS OF USE | AMGEN INC. (US) | 2012-08-16 | — | — | WO | disclosed |
| WO-2012109165-A1 | 5-AMINO-OXAZEPINE AND 5-AMINO-THIAZEPANE COMPOUNDS AS BETA-SECRETASE ANTAGONISTS AND METHODS OF USE | AMGEN INC. (US) | 2012-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140031340-A1 | 5-Amino-Oxazepine and 5-Amino-Thiazepane Compounds as Beta Secretase Antagonists and Methods of Use | BACE1, BACE2, APP | BACE1 1/4885KCNH2 1895/4885CTSD 976/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.