Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 11/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.33 |
| ▸ | PIK3R1 | P27986 | 6/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12472992 | 0.92 | MAPK8 (0.33) | MAPK1HTTTAAR1PIK3CGPIK3CD | |
| SCHEMBL12472028 | 0.91 | PIK3CG (0.33) | MAPK1HTTTAAR1PIK3CGPIK3CD | |
| SCHEMBL12472023 | 0.88 | HTT (0.35) | MAPK1HTTTAAR1PIK3CGPIK3CD | |
| SCHEMBL12472245 | 0.87 | CDK1 (0.37) | HTTALDH1A1MAPTHPGDLMNA | |
| SCHEMBL12472542 | 0.87 | CDK1 (0.37) | HTTPIK3CDSMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL12472654 | 0.84 | PIK3CD (0.37) | MAPK1HTTTAAR1PIK3CGPIK3CD | |
| SCHEMBL12471996 | 0.83 | RPS6KB1 (0.44) | MAPK1HTTTAAR1PDPK1RPS6KB1 | |
| SCHEMBL11901940 | 0.80 | PIK3CD (0.49) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL5607282 | 0.80 | PIK3CD (0.41) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 | |
| SCHEMBL5606978 | 0.80 | PIK3CG (0.51) | PIK3CGPIK3CDPIK3CBPIK3CAPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2673269-A1 | HETEROCYCLIC COMPOUNDS AS PI3 KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-12-18 | — | — | EP | claimed |
| WO-2012107465-A1 | HETEROCYCLIC COMPOUNDS AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-08-16 | — | — | WO | claimed |
| EP-2673269-A1 | HETEROCYCLIC COMPOUNDS AS PI3 KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2013-12-18 | — | — | EP | disclosed |
| WO-2012107465-A1 | HETEROCYCLIC COMPOUNDS AS PI3 KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2012-08-16 | — | — | WO | disclosed |